Impact of the 2004 mass drug administration for the control of lymphatic filariasis, in urban and rural areas of the Western province of Sri Lanka.
Identifieur interne : 007239 ( Main/Exploration ); précédent : 007238; suivant : 007240Impact of the 2004 mass drug administration for the control of lymphatic filariasis, in urban and rural areas of the Western province of Sri Lanka.
Auteurs : G S A. Gunawardena [Sri Lanka] ; M M Ismail ; M H Bradley ; N D KarunaweeraSource :
- Annals of tropical medicine and parasitology [ 0003-4983 ] ; 2007.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Albendazole (usage thérapeutique), Animaux, Antihelminthiques (usage thérapeutique), Diéthylcarbamazine (usage thérapeutique), Enfant, Enfant d'âge préscolaire, Femelle, Filaricides (usage thérapeutique), Filariose lymphatique (), Filariose lymphatique (traitement médicamenteux), Filariose lymphatique (épidémiologie), Humains, Microfilaria (), Mâle, Observance thérapeutique, Services de médecine préventive (organisation et administration), Sri Lanka (épidémiologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Études transversales.
- MESH :
- organisation et administration : Services de médecine préventive.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Albendazole, Antihelminthiques, Diéthylcarbamazine, Filaricides.
- épidémiologie : Filariose lymphatique, Sri Lanka.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Enfant, Enfant d'âge préscolaire, Femelle, Filariose lymphatique, Humains, Microfilaria, Mâle, Observance thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Études transversales.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Albendazole (therapeutic use), Animals, Anthelmintics (therapeutic use), Child, Child, Preschool, Cross-Sectional Studies, Diethylcarbamazine (therapeutic use), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (prevention & control), Female, Filaricides (therapeutic use), Humans, Male, Microfilariae (drug effects), Middle Aged, Patient Compliance, Preventive Health Services (organization & administration), Sri Lanka (epidemiology).
- MESH :
- chemical , therapeutic use : Albendazole, Anthelmintics, Diethylcarbamazine, Filaricides.
- drug effects : Microfilariae.
- drug therapy : Elephantiasis, Filarial.
- epidemiology : Elephantiasis, Filarial, Sri Lanka.
- organization & administration : Preventive Health Services.
- prevention & control : Elephantiasis, Filarial.
- Adolescent, Adult, Aged, Aged, 80 and over, Animals, Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Patient Compliance.
Abstract
Lymphatic filariasis is targeted to be eliminated globally, at least as a public-health problem, by 2020. The comprehensive strategy for achieving this goal includes the interruption of the transmission of the causative parasites, by drastically reducing the prevalences of microfilaraemia in at-risk communities. In a descriptive, comparative, cross-sectional and community-based study, the impact of the 2004 mass drug administration (MDA) on filarial infection, in selected areas of the Western province of Sri Lanka, has now been assessed 1-2 and 11 months after the administration of the diethylcarbamazine-albendazole combination employed. Using the cluster-sampling method, urban study populations were selected in the Colombo districts and rural ones were selected in the Gampaha district. After obtaining informed written consent, 2 ml venous blood were collected, between 20.00 and 24.00 hours, from each subject. Personal details and drug compliance in the 2004 MDA were recorded. The samples of 'night' blood were checked for microfilariae, using membrane filtration, and for filarial antigenaemia, using commercial (NOW) immunochromatographic test kits. Eighty-four (4.10%) of the 2034 subjects examined 1-2 months after the 2004 MDA but only four (0.20%) of the 1974 subjects checked 11 months after the MDA were found antigenaemic and/or microfilaraemic (P<0.001). Between the two follow-ups, the overall prevalences of both antigenaemia (4.03% v. 0.15%; P<0.001) and microfilaraemia (0.20% v. 0.05%; P=0.38) fell, although only the reduction in antigenaemia was statistically significant. The prevalence of infection (as indicated by antigenaemia and/or microfilaraemia) fell significantly within each of the two study districts (P<0.001). Although, when the prevalence of infection was high, drug compliance appeared to be an important determinant of the reduction of antigenaemia (P=0.04), the 20% difference in compliance between urban and rural areas had no apparent effect on the corresponding prevalences of infection recorded at either follow-up.
DOI: 10.1179/136485907X176364
PubMed: 17524248
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 003642
- to stream PubMed, to step Curation: 003642
- to stream PubMed, to step Checkpoint: 003642
- to stream Ncbi, to step Merge: 002727
- to stream Ncbi, to step Curation: 002727
- to stream Ncbi, to step Checkpoint: 002727
- to stream Main, to step Merge: 007381
- to stream Main, to step Curation: 007239
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Impact of the 2004 mass drug administration for the control of lymphatic filariasis, in urban and rural areas of the Western province of Sri Lanka.</title><author><name sortKey="Gunawardena, G S A" sort="Gunawardena, G S A" uniqKey="Gunawardena G" first="G S A" last="Gunawardena">G S A. Gunawardena</name><affiliation wicri:level="1"><nlm:affiliation>Department of Parasitology, Faculty of Medicine, University of Colombo, PO Box 271, Kynsey Road, Colombo 8, Sri Lanka. sharminigunawardena@hotmail.com</nlm:affiliation><country xml:lang="fr">Sri Lanka</country><wicri:regionArea>Department of Parasitology, Faculty of Medicine, University of Colombo, PO Box 271, Kynsey Road, Colombo 8</wicri:regionArea><wicri:noRegion>Colombo 8</wicri:noRegion></affiliation></author><author><name sortKey="Ismail, M M" sort="Ismail, M M" uniqKey="Ismail M" first="M M" last="Ismail">M M Ismail</name></author><author><name sortKey="Bradley, M H" sort="Bradley, M H" uniqKey="Bradley M" first="M H" last="Bradley">M H Bradley</name></author><author><name sortKey="Karunaweera, N D" sort="Karunaweera, N D" uniqKey="Karunaweera N" first="N D" last="Karunaweera">N D Karunaweera</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17524248</idno><idno type="pmid">17524248</idno><idno type="doi">10.1179/136485907X176364</idno><idno type="wicri:Area/PubMed/Corpus">003642</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003642</idno><idno type="wicri:Area/PubMed/Curation">003642</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003642</idno><idno type="wicri:Area/PubMed/Checkpoint">003642</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003642</idno><idno type="wicri:Area/Ncbi/Merge">002727</idno><idno type="wicri:Area/Ncbi/Curation">002727</idno><idno type="wicri:Area/Ncbi/Checkpoint">002727</idno><idno type="wicri:doubleKey">0003-4983:2007:Gunawardena G:impact:of:the</idno><idno type="wicri:Area/Main/Merge">007381</idno><idno type="wicri:Area/Main/Curation">007239</idno><idno type="wicri:Area/Main/Exploration">007239</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Impact of the 2004 mass drug administration for the control of lymphatic filariasis, in urban and rural areas of the Western province of Sri Lanka.</title><author><name sortKey="Gunawardena, G S A" sort="Gunawardena, G S A" uniqKey="Gunawardena G" first="G S A" last="Gunawardena">G S A. Gunawardena</name><affiliation wicri:level="1"><nlm:affiliation>Department of Parasitology, Faculty of Medicine, University of Colombo, PO Box 271, Kynsey Road, Colombo 8, Sri Lanka. sharminigunawardena@hotmail.com</nlm:affiliation><country xml:lang="fr">Sri Lanka</country><wicri:regionArea>Department of Parasitology, Faculty of Medicine, University of Colombo, PO Box 271, Kynsey Road, Colombo 8</wicri:regionArea><wicri:noRegion>Colombo 8</wicri:noRegion></affiliation></author><author><name sortKey="Ismail, M M" sort="Ismail, M M" uniqKey="Ismail M" first="M M" last="Ismail">M M Ismail</name></author><author><name sortKey="Bradley, M H" sort="Bradley, M H" uniqKey="Bradley M" first="M H" last="Bradley">M H Bradley</name></author><author><name sortKey="Karunaweera, N D" sort="Karunaweera, N D" uniqKey="Karunaweera N" first="N D" last="Karunaweera">N D Karunaweera</name></author></analytic><series><title level="j">Annals of tropical medicine and parasitology</title><idno type="ISSN">0003-4983</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Albendazole (therapeutic use)</term><term>Animals</term><term>Anthelmintics (therapeutic use)</term><term>Child</term><term>Child, Preschool</term><term>Cross-Sectional Studies</term><term>Diethylcarbamazine (therapeutic use)</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Elephantiasis, Filarial (epidemiology)</term><term>Elephantiasis, Filarial (prevention & control)</term><term>Female</term><term>Filaricides (therapeutic use)</term><term>Humans</term><term>Male</term><term>Microfilariae (drug effects)</term><term>Middle Aged</term><term>Patient Compliance</term><term>Preventive Health Services (organization & administration)</term><term>Sri Lanka (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Albendazole (usage thérapeutique)</term><term>Animaux</term><term>Antihelminthiques (usage thérapeutique)</term><term>Diéthylcarbamazine (usage thérapeutique)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Filaricides (usage thérapeutique)</term><term>Filariose lymphatique ()</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Filariose lymphatique (épidémiologie)</term><term>Humains</term><term>Microfilaria ()</term><term>Mâle</term><term>Observance thérapeutique</term><term>Services de médecine préventive (organisation et administration)</term><term>Sri Lanka (épidémiologie)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études transversales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Albendazole</term><term>Anthelmintics</term><term>Diethylcarbamazine</term><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Microfilariae</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Sri Lanka</term></keywords><keywords scheme="MESH" qualifier="organisation et administration" xml:lang="fr"><term>Services de médecine préventive</term></keywords><keywords scheme="MESH" qualifier="organization & administration" xml:lang="en"><term>Preventive Health Services</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Albendazole</term><term>Antihelminthiques</term><term>Diéthylcarbamazine</term><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Sri Lanka</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Animals</term><term>Child</term><term>Child, Preschool</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Patient Compliance</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Filariose lymphatique</term><term>Humains</term><term>Microfilaria</term><term>Mâle</term><term>Observance thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études transversales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphatic filariasis is targeted to be eliminated globally, at least as a public-health problem, by 2020. The comprehensive strategy for achieving this goal includes the interruption of the transmission of the causative parasites, by drastically reducing the prevalences of microfilaraemia in at-risk communities. In a descriptive, comparative, cross-sectional and community-based study, the impact of the 2004 mass drug administration (MDA) on filarial infection, in selected areas of the Western province of Sri Lanka, has now been assessed 1-2 and 11 months after the administration of the diethylcarbamazine-albendazole combination employed. Using the cluster-sampling method, urban study populations were selected in the Colombo districts and rural ones were selected in the Gampaha district. After obtaining informed written consent, 2 ml venous blood were collected, between 20.00 and 24.00 hours, from each subject. Personal details and drug compliance in the 2004 MDA were recorded. The samples of 'night' blood were checked for microfilariae, using membrane filtration, and for filarial antigenaemia, using commercial (NOW) immunochromatographic test kits. Eighty-four (4.10%) of the 2034 subjects examined 1-2 months after the 2004 MDA but only four (0.20%) of the 1974 subjects checked 11 months after the MDA were found antigenaemic and/or microfilaraemic (P<0.001). Between the two follow-ups, the overall prevalences of both antigenaemia (4.03% v. 0.15%; P<0.001) and microfilaraemia (0.20% v. 0.05%; P=0.38) fell, although only the reduction in antigenaemia was statistically significant. The prevalence of infection (as indicated by antigenaemia and/or microfilaraemia) fell significantly within each of the two study districts (P<0.001). Although, when the prevalence of infection was high, drug compliance appeared to be an important determinant of the reduction of antigenaemia (P=0.04), the 20% difference in compliance between urban and rural areas had no apparent effect on the corresponding prevalences of infection recorded at either follow-up.</div></front></TEI><affiliations><list><country><li>Sri Lanka</li></country></list><tree><noCountry><name sortKey="Bradley, M H" sort="Bradley, M H" uniqKey="Bradley M" first="M H" last="Bradley">M H Bradley</name><name sortKey="Ismail, M M" sort="Ismail, M M" uniqKey="Ismail M" first="M M" last="Ismail">M M Ismail</name><name sortKey="Karunaweera, N D" sort="Karunaweera, N D" uniqKey="Karunaweera N" first="N D" last="Karunaweera">N D Karunaweera</name></noCountry><country name="Sri Lanka"><noRegion><name sortKey="Gunawardena, G S A" sort="Gunawardena, G S A" uniqKey="Gunawardena G" first="G S A" last="Gunawardena">G S A. Gunawardena</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 007239 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 007239 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:17524248
|texte= Impact of the 2004 mass drug administration for the control of lymphatic filariasis, in urban and rural areas of the Western province of Sri Lanka.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:17524248" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |